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Merck
CN

PZ0148

CP-802079 hydrochloride hydrate

≥98% (HPLC)

Synonym(s):

({3-(4-Chlorophenyl)-3-[4-(thiazole-carbonyl)-phenoxy]-propyl}-methyl-amino)-acetic acid hydrochloride hydrate, N-[3-(4-Chlorophenyl)-3-[4-(2-thiazolylcarbonyl)phenoxy]propyl]-N-methyl-glycine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C22H21ClN2O4S · xHCl · yH2O
CAS Number:
736175-49-8
Molecular Weight:
444.93 (anhydrous free base basis)
NACRES:
NA.77
PubChem Substance ID:
329823733
UNSPSC Code:
51111800
MDL number:
MFCD18452850

Key Documents

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InChI key

CVQXAUBKPDYXHF-UHFFFAOYSA-N

SMILES string

O.Cl.CN(CCC(Oc1ccc(cc1)C(=O)c2nccs2)c3ccc(Cl)cc3)CC(O)=O

InChI

1S/C22H21ClN2O4S.ClH.H2O/c1-25(14-20(26)27)12-10-19(15-2-6-17(23)7-3-15)29-18-8-4-16(5-9-18)21(28)22-24-11-13-30-22;;/h2-9,11,13,19H,10,12,14H2,1H3,(H,26,27);1H;1H2

assay

≥98% (HPLC)

form

powder

color

very light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

CP-802079 is a potent and selective GlyT1 antagonist.
CP-802079 is a potent and selective glycine transporter type 1 (GlyT1) antagonist. Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, they can augment NMDAR currents and NMDAR-mediated functions. CP-802,079 significantly increases the amplitude of the NMDAR currents and LTP.

Features and Benefits

This compound is featured on the Glycine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000040793
0000040106
090M4717

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