Skip to Content
Merck
CN

PZ0250

PF-04859989 hydrochloride

≥98% (HPLC), KAT II inhibitor, powder

Synonym(s):

(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one; L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride, PF-4859989 hydrochloride, PF04859989 hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C9H10N2O2 · HCl
CAS Number:
177943-33-8
Molecular Weight:
214.65
UNSPSC Code:
51111800
PubChem Substance ID:
329823792
NACRES:
NA.77
MDL number:
MFCD22419400

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

PF-04859989 hydrochloride, ≥98% (HPLC)

SMILES string

N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl

InChI key

WZOBDOKCHIUXAY-FJXQXJEOSA-N

InChI

1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

Related Categories

Biochem/physiol Actions

PF-04859989 is a a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II).
PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000121388
0000121389
0000108592
0000108593
0000029782

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

George Zakhary et al.
Journal of neuroscience research, 98(1), 155-167 (2019-07-02)
Neurosurgical procedures result in surgically induced brain injury (SBI) that causes postoperative complications including brain edema and neuronal apoptosis in the surrounding brain tissue. SBI leads to the release of cytokines that indirectly cause the stimulation of kynurenine 3-monooxygenase (KMO)

Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service