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Merck
CN

PZ0294

PF-04880594

≥98% (HPLC)

Synonym(s):

3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-propanenitrile, PF 04880594

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About This Item

Empirical Formula (Hill Notation):
C19H16F2N8
CAS Number:
1111636-35-1
Molecular Weight:
394.38
NACRES:
NA.77
UNSPSC Code:
12352200

Key Documents

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InChI

1S/C19H16F2N8/c20-16(21)11-29-10-14(15-3-7-25-19(27-15)24-5-1-4-22)17(28-29)13-8-12-2-6-23-18(12)26-9-13/h2-3,6-10,16H,1,5,11H2,(H,23,26)(H,24,25,27)

InChI key

HFYMVDKBZONUOJ-UHFFFAOYSA-N

SMILES string

FC(F)CN(N=C1C2=CC(C=CN3)=C3N=C2)C=C1C4=NC(NCCC#N)=NC=C4

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000044875
065M4752V

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