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Merck
CN

PZ0324

PF-06263276

≥98% (HPLC)

Synonym(s):

PF06263276, [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(1-piperidinyl)-2-pyrazinyl]-methanone

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About This Item

Empirical Formula (Hill Notation):
C31H31FN8O2
CAS Number:
1421502-62-6
Molecular Weight:
566.63
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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InChI

1S/C31H31FN8O2/c1-2-18-13-27(41)22(32)14-21(18)19-6-7-20-24(12-19)37-38-29(20)30-35-23-8-11-40(17-26(23)36-30)31(42)25-15-34-28(16-33-25)39-9-4-3-5-10-39/h6-7,12-16,41H,2-5,8-11,17H2,1H3,(H,35,36)(H,37,38)

InChI key

XDJGNPSZQSWJCV-UHFFFAOYSA-N

SMILES string

FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CCN(C(C6=CN=C(N7CCCCC7)C=N6)=O)C5)N4)=C3C=C2)=C1

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

PF-06263276 is an inhibitor of the Janus kinase (JAK) enzymes 1, 2, 3 and tyrosine kinase 2 (TYK2). PF-06263276 has been investigated for the treatment of psoriasis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
036M4714V

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Peter Jones et al.
Journal of medicinal chemistry, 60(2), 767-786 (2016-12-17)
By use of a structure-based computational method for identification of structurally novel Janus kinase (JAK) inhibitors predicted to bind beyond the ATP binding site, a potent series of indazoles was identified as selective pan-JAK inhibitors with a type 1.5 binding

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