PZ0377
PF-05236216 hydrochloride
≥98% (HPLC)
别名:
4-[3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-6-methyl-5H-pyrrolo[3,4-b]pyridin-5-one hydrochloride, PF-5236216 hydrochloride
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN1C=C(C2=CC=NC(CN3C)=C2C3=O)C(C4=CC=C(F)C=C4)=N1.Cl
InChI
1S/C18H15FN4O.ClH/c1-22-10-15-16(18(22)24)13(7-8-20-15)14-9-23(2)21-17(14)11-3-5-12(19)6-4-11;/h3-9H,10H2,1-2H3;1H
InChI key
CLDJMFXSCFWXDI-UHFFFAOYSA-N
Biochem/physiol Actions
PF-05236216 is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhythms in mice.
brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable