Skip to Content
Merck
CN

PZ0391

PF-06745268

≥98% (HPLC)

Synonym(s):

2-[[(1aS,7bS)-1a,2-Dihydro-2,2-dimethyl-6-(trifluoromethyl)benzo[b]cyclopropa[d]pyran-7b(1H)-yl]methyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-2H-pyrido[1,2-a]pyrazine-1,6-dione

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C26H25F3N4O3
CAS Number:
1812190-38-7
Molecular Weight:
498.50
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

LHTSLMHEFKNOOX-PXDATVDWSA-N

SMILES string

O=C1C(N2C=C(N=C2)C)=CC=C3N1CCN(C[C@@]4(C5)[C@@]5([H])C(C)(C)OC6=C4C=C(C(F)(F)F)C=C6)C3=O

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -13 to -17°, c = 1.0 in methanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

PF-06745268 is an orally available, brain penetrant, potent and selective γ-secretase modulator. PF-06745268 induces robust and sustained reduction of brain amyloid-β42 (Aβ42) in rats.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000038463
0000038464
0000035496

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service