Skip to Content
Merck
CN

R8407

Anti-RAB25 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CATX-8

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Anti-RAB25 antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~25 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

western blot: 1-2 μg/mL using whole extracts of human A431 cells

UniProt accession no.

P57735

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... RAB25(57111)

Application

Anti-RAB25 antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Anti-Rab25 recognizes human Rab25 (not tested in other species).
Ras-related protein Rab-25 (Rab25) acts as an oncogene or a tumor suppressor gene. Overexpression of this gene is seen in several cancers such as ovarian cancer, bladder cancer, breast cancer, gastric cancer, liver cancer, non-small cell lung cancer, renal cancer, glioblastoma multiforme and prostate cancer. It helps to control the vesicle trafficking and signaling pathways. Rab25 is associated with the apical recycling system of epithelial cells. Antibodies to Rab proteins may serve as useful tools for studying subcellular localization and membrane organization.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Ras-related protein Rab-25 (Rab25) is a member of the Rab family of small guanosine triphosphatases (GTPases). The Rab family belongs to the Ras superfamily of small GTPases. Rab25 is specifically expressed in epithelial cells and is localized on human chromosome 1q22. It comprises a GTPase tertiary structure with a central barrel with a six-stranded β-sheet surrounded by α-helices.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

Store at –20 °C. For continuous use, the product maybe stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Not finding the right product?  

Try our Product Selector Tool.

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
099K4768

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Rab25 GTPase: Functional roles in cancer
Wang S, et al.
Testing, 8(38), 64591-64591 (2017)

Related Content

Data Sheet - R8407

Instructions

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service