Name: SCH-28080
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₅N₃O

CAS Number:

76081-98-6

Molecular Weight:

277.32

MDL number:

MFCD00834620

UNSPSC Code:

12352200

PubChem Substance ID:

24278810

NACRES:

NA.77

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Product Name

SCH-28080, ≥98% (HPLC), solid

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

white to light tan

solubility

DMSO: soluble >10 mg/mL
H₂O: insoluble

compatibility

for use with ABI 7700

storage temp.

−20°C

SMILES string

Cc1nc2c(OCc3ccccc3)cccn2c1CC#N

InChI

1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3

InChI key

PYKJFEPAUKAXNN-UHFFFAOYSA-N

Application

SCH-28080 was used to treat zebrafish embryos to study the role of H⁺/K⁺-ATPase in establishment of left-right axis during development.

Biochem/physiol Actions

SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC₅₀s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC₅₀ of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.

SCH-28080 is a potent inhibitor of gastric H⁺and K⁺-ATPase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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