S6768
N-Succinyl-Phe-Gly-Leu-β-naphthylamide
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About This Item
Empirical Formula (Hill Notation):
C31H36N4O6
CAS Number:
Molecular Weight:
560.64
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
InChI
1S/C31H34N4O5/c1-20(2)16-25(30(39)33-24-13-12-22-10-6-7-11-23(22)18-24)34-27(36)19-32-31(40)26(17-21-8-4-3-5-9-21)35-28(37)14-15-29(35)38/h3-13,18,20,25-26H,14-17,19H2,1-2H3,(H,32,40)(H,33,39)(H,34,36)
SMILES string
CC(C)CC(NC(=O)CNC(=O)C(Cc1ccccc1)N2C(=O)CCC2=O)C(=O)Nc3ccc4ccccc4c3
InChI key
SGVJLMFFXDTAFJ-UHFFFAOYSA-N
form
solid
storage temp.
−20°C
Quality Level
General description
Substrate for an LHRH-degrading neutral endopeptidase
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B Horsthemke et al.
Biochemistry, 19(13), 2867-2873 (1980-06-24)
A neutral endopeptidase which degrades luteinizing hormone-releasing hormone (LH-RH, <GLu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GLy-NH2) has been purified 900-fold from extracts of bovine anterior pituitary. This Ca2+-independent enzyme of 83 000 molecular weight (as estimated by gel filtration) cleaves LH-RH (KM = 180 microM) at
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