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Merck
CN

SAB1306492

ANTI-ZO1(C-TERMINAL) antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

TJP1, Tight junction protein 1, Tight junction protein ZO-1, ZO1, Zona occludens protein 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

195459 Da

species reactivity

human

technique(s)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI accession no.

NP_003248.3

UniProt accession no.

Q07157

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TJP1(7082)

General description

Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) is an adaptor protein. It acts as a scaffold protein between the tight junction and actin cytoskeleton. ZO1 has a molecular weight of 220kDa and is part of the membrane-associated guanylate kinase homolog family. The protein possesses three PDZ domains at its amino terminal, an SH3 domain and a region which bears homology to guanylate kinase. The ZO1 gene is localized on human chromosome 15q13.1.

Application

ANTI-ZO1(C-TERMINAL) antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions

Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) has a role in the formation of epithelial lumens. It interacts with occludin and modulates tight junction barrier regulation. ZO1 is also involved in the formation of the odontoblast layer and in actomyosin cytoskeleton regulation. Low expression of ZO1 has been linked to increased cell invasiveness in breast cancer, colorectal cancer and digestive tract cancers.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SH080711D

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The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks.
Van Itallie CM, et al.
Journal de Biologie Buccale (2013)
Genome-wide association study of patient and clinician rated global impression severity during antipsychotic treatment
Shaunna L, et al.
Pharmacogenetics and Genomics (2013)
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
Tornavaca O, et al.
Journal of Cellular Biochemistry (2015)
Novel role of zonula occludens-1: A tight junction protein closely associated with the odontoblast differentiation of human dental pulp cells.
Xu J, et al.
Cell Biol. (2016)
ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture.
Odenwald MA, et al.
Journal of Cell Science (2017)
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