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SAB1402803

Monoclonal Anti-HEXA antibody produced in mouse

clone 3D1, purified immunoglobulin, buffered aqueous solution

Synonym(s):

MGC99608, TSD

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Monoclonal Anti-HEXA antibody produced in mouse, clone 3D1, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3D1, monoclonal

form

buffered aqueous solution

mol wt

antigen ~84.3 kDa

species reactivity

human

technique(s)

immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

NCBI accession no.

BC018927

UniProt accession no.

P06865

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... HEXA(3073)

Biochem/physiol Actions

Hexosaminidase subunit alpha (HEXA) degrades the carbohydrate moieties of glycoproteins, glycolipids and proteoglycans. Mutations in the α chain of HEXA impairs folding, trafficking and enzyme assembly. Lysosomal β-hexosaminidase α subunit is downregulated in prostate cancer cells due to hypermethylation of gene promoter.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Hexosaminidase subunit alpha (HEXA) gene is located on the human chromosome 15q23-q24. HEXA is found to be associated with the external leaflet of plasma membrane of human fibroblasts. α and β subunits of HEXA have 57% of similarity in their amino acid sequences.

Immunogen

HEXA (AAH18927, 1 a.a. ~ 529 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
10274-3D1

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The X-ray crystal structure of human $\beta$-hexosaminidase B provides new insights into Sandhoff disease
Maier T, et al.
Journal of Molecular Biology, 328(3), 669-681 (2003)
Hypermethylation contributes to down-regulation of lysosomal beta-hexosaminidase alpha subunit in prostate cancer cells
Costanzi E, et al.
Biochimie, 101, 75-82 (2014)
Specific mutations in the HEXA gene among Iraqi Jewish Tay-Sachs disease carriers: dating of founder ancestor
Karpati M, et al.
Neurogenetics, 5(1), 35-40 (2004)
Identification of plasma membrane associated mature beta-hexosaminidase A, active towards GM2 ganglioside, in human fibroblasts
Mencarelli S, et al.
Febs Letters, 579(25), 5501-5506 (2005)
Tay-Sachs disease mutations in HEXA target the alpha chain of hexosaminidase A to endoplasmic reticulum-associated degradation
Dersh D, et al.
Molecular Biology of the Cell, 27(24), 3813-3827 (2016)
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