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Merck
CN

SAB1403506

Monoclonal Anti-MAP3K15 antibody produced in mouse

clone 1H7, purified immunoglobulin, buffered aqueous solution

Synonym(s):

FLJ16518, bA723P2.3

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Monoclonal Anti-MAP3K15 antibody produced in mouse, clone 1H7, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1H7, monoclonal

form

buffered aqueous solution

mol wt

antigen ~36.67 kDa

species reactivity

human

technique(s)

capture ELISA: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2bκ

NCBI accession no.

NM_001001671

UniProt accession no.

Q6ZN16

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MAP3K15(389840)

Biochem/physiol Actions

Mitogen-activated protein kinase kinase kinase 15 (MAP3K15) modulates blood pressure in the kidney. It has a role in signal transduction cascades related to apoptotic cell death initiated due to cellular stress. ASK3 has been shown to protect HeLa cells against cytotoxicity induced by oxidative stress, antibodies or proteins.

General description

Mitogen-activated protein kinase kinase kinase 15 (MAP3K15) belongs to the group of apoptosis signal-regulating kinases. It is expressed in the kidney and the gene encoding it is localized on human chromosome Xp22.12.

Immunogen

MAP3K15 (NP_001001671, 691 a.a. ~ 786 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
LYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKD

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
08165-1H7

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MAP7D2 is a brain expressing X-linked maternal imprinted gene in humans
Yo NIIDA
Natural Products Journal (2011)
ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.
Naguro I
Nature Communications (2012)
ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells.
Kaji T
Biochemical and Biophysical Research Communications (2010)

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