SAB1406267
Anti-PLSCR1 antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
Synonym(s):
MMTRA1B
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
6
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~35 kDa
species reactivity
human
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PLSCR1(5359)
General description
Phospholipid scramblase 1 (PLSCR1) is a 35kDa calcium dependant phospholipid translocator. The gene is located on human chromosome 3q24. The protein is overexpressed in tumor cells.
Immunogen
PLSCR1 (NP_066928.1, 1 a.a. ~ 318 a.a) full-length human protein.
Sequence
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW
Sequence
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW
Biochem/physiol Actions
Phospholipid scramblase 1 (PLSCR1) bidirectionally transfers lipids across the membranes. It negatively regulates autophagy in mantle cell lymphoma (MCL). This protein is known to scramble phospholipids in the plasma membrane and thereby, disrupt membrane asymmetry. It functions as a multifunctional signalling molecule. It also has nuclease activity. PLSCR1 plays a role in cell proliferation, differentiation, apoptosis, pathogenesis of cancers, particularly leukemia.
Physical form
Solution in phosphate buffered saline, pH 7.4
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1
Sivagnanam U, et al.
BMC Biochemistry, 17(1), 10-10 (2016)
Biochemical evidence for Ca2+-independent functional activation of hPLSCR1 at low pH
Francis VG, et al.
Cellular & Molecular Biology Letters, 20(2), 177-195 (2015)
Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma
Mastorci K, et al.
Oncotarget, 7(27), 41913-41913 (2016)
Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites
Girirajan S, et al.
Genome Research (2009)
Phospholipid scramblase 1
Huang Y, et al.
Sheng li xue bao : [Acta physiologica Sinica], 58(6), 501-510 (2006)
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