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SAB1406915

Sigma-Aldrich

Anti-TOM1L1 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

OK/KNS-CL.3, SRCASM

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~38.7 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

BC029396.1

UniProt accession no.

O75674

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TOM1L1(10040)

General description

Mouse polyclonal antibody raised against a full-length human TOM1L1 protein.
The gene TOM1L1 (target of myb1 like 1 membrane trafficking) is mapped to human chromosome 17q23.(5) The protein has a VHS (Vps27p/Hrs/Stam) domain at the N-terminal, a GAT (GGA (Golgi-localizing, ?-adaptin ear domain homology, ADP-ribosylation factor (Arf)-binding protein and Tom) domain at the center and interaction motifs at the C-terminal.1,2

Immunogen

TOM1L1 (AAH29396.1, 1 a.a. ~ 346 a.a) full-length human protein.

Sequence
MAFGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSPSPRMPRATLGELNTMNNQLSGLSK

Biochem/physiol Actions

TOM1L1 (target of myb1 like 1 membrane trafficking) is an adaptor protein, which is involved in vesicular trafficking as well as intracellular signaling. It negatively controls the mitogenic and transforming functions in fibroblasts by working as a substrate for SRC (tyrosine protein kinase).1,2 It is involved in EGF (epidermal growth factor)-mediated internalization of EGF receptor.4 TOM1L1 is downregulated in cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma.3

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
10139

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