SAB2501420
Anti-PEBP4 (C-terminal) antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CORK-1, Anti-CORK1, Anti-GWTM1933, Anti-MGC22776, Phosphatidylethanolamine-binding protein 4
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PEBP4(157310)
General description
The gene PEBP4 (phosphatidylethanolamine binding protein 4) is mapped to human chromosome 8p21.3. It belongs to the PEBP family of proteins. The protein has potential glycosylation sites and can be secreted. It is mainly expressed in the skeletal muscle, heart and thyroid.
Immunogen
Peptide with sequence RERASEPKHKNQAE, from the C-terminal region of the protein sequence according to NP_659399.2
Biochem/physiol Actions
PEBP4 (phosphatidylethanolamine binding protein 4) regulates apoptosis by associating with Raf1 (proto-oncogene serine/threonine-protein kinase) and MEK1 (MAPK/ERK kinase 1). This association blocks TNFα (tumor necrosis α) or TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) - mediated activation of MEK/ERK (extracellular signal-regulated kinase). PEBP4 is also involved in myoblast differentiation. Additionally, it promotes Akt (RAC-α serine/threonine-protein kinase) activation. The gene is expressed in various cancers and is associated with cancer progression. The PEBP4 mRNA is a target of microRNA miR-34a.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Li Chushi et al.
Gene, 587(1), 42-47 (2016-04-18)
Alteration of metabolic profile is one of the hallmarks of cancer cells. Statin, the inhibitors for synthesis of cholesterol, has shown anti-cancer effects on the gastric cancer cells. However, the functions of its target, HMGCR, in the progression of gastric
Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions.
Huan He et al.
Biochimica et biophysica acta, 1863(7 Pt A), 1682-1689 (2016-04-02)
Phosphatidylethanolamine binding proteins (PEBP) represent a superfamily of proteins that are conserved from bacteria to humans. In mammals, four members have been identified, PEBP1-4. To determine the functional differences among PEBP1-4 and the underlying mechanism for their actions, we performed
Guiping Yu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 10341-10349 (2014-07-21)
The aim of this study was to determine the relationship and underlying mechanisms between ectopic expression of phosphatidylethanolamine-binding protein 4 (PEBP4) and cisplatin (DDP)-induced cytotoxicity in the lung cancer cell line A549 to provide an experimental basis for future chemotherapeutic
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