SAB2501761
Anti-ZNF703 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
FLJ14299, ZNF503L, hypothetical protein LOC80139, zinc finger protein 703
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
4
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
pig, canine, human
technique(s)
indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ZNF703(80139)
General description
ZNF703 (zinc finger protein 703) belongs to the NET (Noc/Nlz, Elbow, and Tlp-1) protein family, and the corresponding gene is localized to human chromosome 8p12.
Immunogen
Peptide with sequence C-ELDKKDQEPKPSPE, from the internal region of the protein sequence according toNP_079345.1
Biochem/physiol Actions
ZNF703 (zinc finger protein 703) is a frequently modified gene in the pan-cancer group. In zebrafish and Drosophila, it plays an essential role in embryonic development. Amplification of this gene leads to loss of cell-cell adhesion, and thus, an increase in proliferation and migration. In patients with head and neck squamous cell carcinomas (HNSCC), the overexpression of this protein is linked with poor overall survival. It functions as an oncogene in luminal B breast cancer and gastric cancer, and in colorectal cancer (CRC) it facilitates tumor proliferation and invasion. In CRC patients, it is linked with poor prognosis.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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ZNF703 promotes tumor cell proliferation and invasion and predicts poor prognosis in patients with colorectal cancer.
Ma F et al
Oncology Reports, 32(3), 1071-1077 (2014)
ZNF703 acts as an oncogene that promotes progression in gastric cancer.
Yang G et al
Oncology Reports, 31(4), 1877-1882 (2014)
Hang Yang et al.
Disease markers, 2015, 640263-640263 (2015-06-13)
Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear. The purpose of this study was
High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.
Reynisdottir I et al
Cancer Medicine, 2(4), 437-446 (2013)
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