SAB3500076
Anti-MPYS antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-ERIS, Anti-MITA, Anti-STING, Anti-TMEM173, Anti-Transmembrane protein 173
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), ICC, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 31-42 kDa
species reactivity
mouse, human
technique(s)
immunocytochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TMEM173(340061)
General description
MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.
TMEM173 (transmembrane protein 173) gene is mapped to human chromosome 5q31.2. The encoded protein localizes in the endoplasmic reticulum.
Immunogen
MPYS antibody was raised against a 17 amino acid peptide near the carboxy terminus of human MPYS.
Biochem/physiol Actions
The innate immune response against the viral and bacterial infections is mostly regulated by TMEM173 (transmembrane protein 173), also known as stimulator of interferon genes (STING). It is considered as an important adaptor protein for cytosolic DNA sensing pathways. Downregulation of the gene was observed in tumor tissues. TMEM173 acts as a pattern recognition receptor and identifies pathogen-associated molecular patterns. It also mediates signal transduction pathways. TMEM173 is significantly associated with immunity and inflammation.
Features and Benefits
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Physical form
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500076.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.
Christensen MH
The Embo Journal (2016)
Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
Stoddart A
Haematologica (2016)
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.
Vanpouille-Box C
Nature Communications (2017)
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity.
Mao Y
Arteriosclerosis, Thrombosis, and Vascular Biology (2017)
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