SAB3500079
Anti-PALB2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-FANCN, Anti-Partner and localizer of BRCA2
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-PALB2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, rat, human
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PALB2(79728)
Application
Anti-PALB2 antibody produced in rabbit has been used in western blot analysis.
Biochem/physiol Actions
Partner and Localizer of BRCA2 (PALB2) plays a vital role in BRCA2 (breast cancer 2, early onset)-related pathways. The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51 network may allow predictions to be made of the responsiveness of a tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Partner and Localizer of BRCA2 (PALB2) gene with 13 exons is mapped to human chromosome 16p12.2. The gene codes for a 1,186 amino acid protein characterized with a coiled-coil motif at the N terminus and a C-terminal domain containing a series of WD repeats.
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
Immunogen
PALB2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human PALB2.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500079.
Physical form
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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PALB2/FANCN: Recombining Cancer and Fanconi Anemia
Tischkowitz M, et al.
Cancer research, 70, 7353-7359 (2010)
A cell-penetrating antibody inhibits human RAD51 via direct binding
Turchick A, et al.
Nucleic Acids Research, 45, 11782-11799 (2017)
Audrey Turchick et al.
Nucleic acids research, 45(20), 11782-11799 (2017-10-17)
RAD51, a key factor in homology-directed repair (HDR), has long been considered an attractive target for cancer therapy, but few specific inhibitors have been found. A cell-penetrating, anti-DNA, lupus autoantibody, 3E10, was previously shown to inhibit HDR, sensitize tumors to
PALB2 mutations in German and Russian patients with bilateral breast cancer
Bogdanova N, et al.
Breast Cancer Research and Treatment, 126, 545-550 (2011)
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