SAB3701431
Monoclonal Anti-Esrp-1/2 antibody produced in mouse
clone 23A7.C9, purified immunoglobulin
Synonym(s):
Anti-Epithelial splicing regulatory protein 1, Anti-RNA-binding motif protein 35A, Anti-RNA-binding protein 35A, Anti-RNA-binding protein 35B, Anti-Rbm35a
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
23A7.C9, monoclonal
Application:
ELISA, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
23A7.C9, monoclonal
form
buffered aqueous solution
species reactivity
mouse
technique(s)
ELISA: suitable, western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Esrp2(77411)
General description
Epithelial splicing regulatory protein 1 (ESRP1) is a member of RBM family of RNA-binding proteins. It is also known as RBM35A. ESRP1 get highly expressed in both mouse and human epithelial stem cells and weakly expressed in normal pancreatic ductal cells.
Immunogen
Full length recombinant mouse Esrp-1 fusion protein.
Biochem/physiol Actions
Epithelial splicing regulatory protein 1 (ESRP1) is essential for the expression of epithelial FGFR2-IIIb (fibroblast growth factor receptor 2). Suppression of ESRP1 can enhance induced pluripotent stem (iPS) cell colony generation. It can also repress cancer cell motility by different mechanisms. ESRP1 modulates splicing of Ras-related C3 botulinum toxin substrate 1 (Rac1) isoforms and participates in the maintenance of epithelial cell-specific isoforms. The protein controls epithelial splicing regulatory network and pluripotency.
This antibody was purified from tissue culture supernatant by Protein-A chromatography followed by extensive dialysis against the buffer stated above. This antibody reacts with both mouse Esrp-1 and Esrp-2 proteins. A BLAST analysis of the immunizing protein sequence shows 100% homology with Esrp-1 from mouse and a 91% sequence homology with Esrp-1 from human, pig, rat, opossum, horse, cattle, panda, dog, and chimpanzee . The binding epitope of this monoclonal antibody has not been mapped
Features and Benefits
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Physical form
Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.
Warzecha C C, et al.
RNA Biology, 6(5), 546-562 (2009)
The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.
Fagoonee S, et al.
PLoS ONE, 8(8), e72300-e72300 (2013)
Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.
Ishii H, et al.
The Journal of Biological Chemistry, 289(40), 27386-27399 (2014)
Claude C Warzecha et al.
Molecular cell, 33(5), 591-601 (2009-03-17)
Cell-type-specific expression of epithelial and mesenchymal isoforms of Fibroblast Growth Factor Receptor 2 (FGFR2) is achieved through tight regulation of mutually exclusive exons IIIb and IIIc, respectively. Using an application of cell-based cDNA expression screening, we identified two paralogous epithelial
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