SAB4200132
Anti-ULK3 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody
Synonym(s):
Anti-unc-51-like kinase 3
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.44
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~1 mg/mL
technique(s)
western blot: 1-2 μg/mL using whole extracts of human U87 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ULK3(25989)
General description
Anti-ULK3 is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human ULK3, conjugated to KLH. Unc-51-like kinase 3 (ULK3) belongs to the ULK family of serine/threonine kinases. ULK3 is an autophagy related protein with an N-terminal kinase domain, which shows high similarity to those of ULK1 and ULK2. ULK3 localizes to the elongating isolation membrane upon autophagy activation.
Application
Anti-ULK3 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Unc-51-like kinase 3 (ULK3) controls abscission timing in response to lagging chromosomes. Overexpression of ULK3 induces autophagy and senescence. ULK3 is also a positive regulator of the Hedgehog signalling pathway.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
Sulli G, et al.
Nature, 553(7688), 351-351 (2018)
mTOR regulation of autophagy
Jung CH, et al.
Febs Letters, 584(7), 1287-1295 (2010)
The ULK1 complex: sensing nutrient signals for autophagy activation
Wong PM, et al.
Autophagy, 9(2), 124-137 (2013)
Gabriele Sulli et al.
Nature, 553(7688), 351-355 (2018-01-11)
The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI
Goruppi , et al.
Testing, 20(10), 2468-2479 (2017)
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