SAB4200795
Anti-Exendin-4 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-Exenatide
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i)
Citations:
-
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
concentration
~1 mg/mL
technique(s)
indirect ELISA: 0.125-0.25 μg/mL using 1 μg/mL Exendin-4 protein for coating
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
General description
Exendin-4 is an incretin mimetic 39-amino-acid peptide found in venom from the Gila monster (Helicoderma suspectum). Exendin-4 belongs to the glucagon-secretin family of peptide hormones and neuropeptides. It acts as a potent agonist of the GLP-1 receptor and is an insulinotropic agent (promotes insulin secretion) with a long half-life.
Exendin-4 mimics the activity of mammalian incretin hormone glucagon-like peptide 1 (GLP-1) and thus play a role in the control of glucose. This includes the secretion of insulin in a glucose-dependent manner, negative regulation of high glucagon secretion, and increased duration of stomach emptying. In type 2 diabetes patients, this peptide can be administered subcutaneously for glycemic control, when metformin is unable to produce adequate results. Exendin-4 promotes the neogeneration and proliferation of β-cells, and thus aids in the regeneration of pancreas. It acts as a ligand to exendin receptor and leads to an elevation of acinar cell cAMP levels.
Anti-Exendin-4 antibody specifically recognizes synthetic Exendin-4 and does not cross react with GLP-1.
Exendin-4 mimics the activity of mammalian incretin hormone glucagon-like peptide 1 (GLP-1) and thus play a role in the control of glucose. This includes the secretion of insulin in a glucose-dependent manner, negative regulation of high glucagon secretion, and increased duration of stomach emptying. In type 2 diabetes patients, this peptide can be administered subcutaneously for glycemic control, when metformin is unable to produce adequate results. Exendin-4 promotes the neogeneration and proliferation of β-cells, and thus aids in the regeneration of pancreas. It acts as a ligand to exendin receptor and leads to an elevation of acinar cell cAMP levels.
Anti-Exendin-4 antibody specifically recognizes synthetic Exendin-4 and does not cross react with GLP-1.
Immunogen
synthetic peptide corresponding to the C-terminal sequence of Heloderma suspectum (Gila monster) Exendin-4 , conjugated to KLH
Application
The antibody may be used in various immunochemical techniques including ELISA
Physical form
Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Other Notes
This product is for R&D use only, not for drug, household, or other uses.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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