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Merck
CN

SAB4301078

Anti-TDP2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

AD022, EAP2, EAPII, TTRAP, hTDP2

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
4

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

41 kDa

species reactivity

human, mouse

concentration

2.6 mg/mL

technique(s)

immunohistochemistry: 1:50- 1:200, western blot: 1:200-1:1000 (Cell Lysate)

isotype

IgG

accession no.

NP_057698.2

UniProt accession no.

O95551

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TDP2(51567)

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General description

Tyrosyl DNA phosphodiesterase-2 (TDP2) is a multi-functional protein and is also called as TTRAP (TNF receptor-associated protein). It is a 5′- tyrosyl DNA phosphodiesterase that belongs to the PML NB (promyelocytic leukemia nuclear body) protein family. TDP2 is mapped to human chromosome 6p22.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human tyrosyl-DNA phosphodiesterase 2

Biochem/physiol Actions

Chromosomal translocations stimulated by DNA topoisomerase II at the time of gene transcription is repressed by tyrosyl DNA phosphodiesterase-2 (TDP2). It is essential to preserve the chromosome stability in human cells. TDP2 participates in cell proliferation, apoptosis and the repair of DNA damage. It promotes cell cycle arrest and apoptosis in osteosarcoma cells.
The antibody detects endogenous levels of total TDP2 protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料
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Certificates of Analysis (COA)

Lot/Batch Number
492637559

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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
Gomez-Herreros F, et al.
Nature Communications, 8(1), 233-233 (2017)
Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells.
Zhou C, et al.
Bmb Reports, 46(2), 113-113 (2013)
Tyrosyl-DNA-phosphodiesterases (tdp1 and tdp2).
Pommier Y, et al.
DNA Repair, 19, 114-129 (2014)
Henrike Johanna Gothe et al.
Molecular cell, 75(2), 267-283 (2019-06-17)
How spatial chromosome organization influences genome integrity is still poorly understood. Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) activities are enriched at chromatin loop anchors with high transcriptional activity. Recurrent DSBs occur at CCCTC-binding factor

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