Skip to Content
Merck
CN

SAB4500043

Anti-G3BP-1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ATP-dependent DNA helicase VIII, G3BP-1, GAP SH3 domain-binding protein 1, HDH-VIII, Ras GTPase-activating protein-binding protein 1

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02262927
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
5

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 52 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

Q13283

UniProt accession no.

Q13283

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... G3BP1(10146)

Looking for similar products? Visit Product Comparison Guide

General description

Anti-G3BP-1 Antibody detects endogenous levels of total G3BP-1 protein.
G3BP1 (ras-GTPase-activating protein SH3 domain-binding protein 1) is a constituent of SGs (stress granules). It is located on human chromosome 5q14.2-5q33.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human G3BP-1.

Immunogen Range: 199-248

Biochem/physiol Actions

G3BP1 (ras-GTPase-activating protein SH3 domain-binding protein 1) blocks the replication of HIV-1 (human immunodeficiency virus) in macrophages and T-cells. In gastric cancer patients, overexpression of G3BP1 leads to imperfect clinical predictions. It is required for the interactions of SG–PB (stress granule-processing bodies).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
217089

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Overexpression of Ras-GTPase-activating protein SH3 domain-binding protein 1 correlates with poor prognosis in gastric cancer patients
Min L, et al.
Histopathology, 67(5), 677-688 (2015)
Novel Role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in Adhesion and Migration of 32D Myeloid Progenitor Cells
Schwarz K, et al.
The Open Hematology Journal, 6 (2012)
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
Aulas A, et al.
The Journal of Cell Biology, 209(1), 73-84 (2015)
G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA
Jimenez VC, et al.
Virology, 486, 94-104 (2015)
Hideaki Matsuki et al.
Genes to cells : devoted to molecular & cellular mechanisms, 18(2), 135-146 (2013-01-03)
Upon exposure to various environmental stresses such as arsenite, hypoxia, and heat shock, cells inhibit their translation and apoptosis and then repair stress-induced alterations, such as DNA damage and the accumulation of misfolded proteins. These types of stresses induce the

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service