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Merck
CN

SAB4501633

Anti-KCNJ5 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

G protein-activated inward rectifier potassium channel 4, GIRK4, Inward rectifier K(+) channel Kir3.4, Potassium channel, inwardly rectifying subfamily J member 5

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-KCNJ5 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 47 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P48544

UniProt accession no.

P48544

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... KCNJ5(3762)

Biochem/physiol Actions

KCNJ5 (potassium voltage-gated channel subfamily J member 5) is associated with aldosteronism, a major cause of secondary hypertension. Mutated KCNJ5 gene affects the polarization of plasma membrane and permit sodium and calcium inflow into the cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Anti-KCNJ5 Antibody detects endogenous levels of total KCNJ5 protein.
KCNJ5 (potassium voltage-gated channel subfamily J member 5) is an inwardly rectifying potassium channel, which is also termed as GIRK4 (G protein-coupled inward rectifier K+ channel 4). It is expressed in the cerebral cortex. This gene is mapped to human chromosome 11q24.

Immunogen

The antiserum was produced against synthesized peptide derived from human KCNJ5.

Immunogen Range: 370-419

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
61265

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Significant linkage to migraine with aura on chromosome 11q24.
Zameel MC, et al.
Human Molecular Genetics, 12(19), 2511?2517-2511?2517 (2003)
Positive association between KCNJ5 rs2604204 (A/C) polymorphism and plasma aldosterone levels, but also plasma renin and angiotensin I and II levels, in newly diagnosed hypertensive Chinese: a case-control study.
Wang H, et al.
Journal of Human Hypertension, 31(7), 457-461 (2017)

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