SAB4502683
Anti-p70 S6 Kinase antibody produced in rabbit
affinity isolated antibody
Synonym(s):
70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, S6K, S6K1, p70 S6 kinase α
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
4
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 59 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RPS6KB1(6198)
General description
Ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1) belongs to the AGC kinase subfamily and comprises a catalytic domain, a linker region, and a putative autoinhibitory domain, in addition to the N-terminal and C-terminal domain. The RPS6KB1 gene is located on human chromosome 17q23.1. It exists in multiple isoforms due to alternative splice events.
Immunogen
The antiserum was produced against synthesized peptide derived from human p70 S6 Kinase.
Immunogen Range: 195-244
Immunogen Range: 195-244
Application
Anti-p70 S6 Kinase antibody produced in rabbit has been used in western blotting (1:1000).
Biochem/physiol Actions
Ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1) undergoes acetylation, phosphorylation, and ubiquitination. It is involved in a variety of functions including glucose homeostasis, cell survival, and proliferation. RPS6KB1 also participates in cell structure and organization. It is implicated in ovarian cancer progression, muscle hypertrophy, aging, immunity, and memory. RPS6KB1 also regulates the replication and transcription of mumps virus (MuV).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Still not finding the right product?
Explore all of our products under Anti-p70 S6 Kinase antibody produced in rabbit
— or —
Try our Product Selector Tool to narrow your options
Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Yu-Di Zhu et al.
Molecular medicine reports, 18(3), 3403-3410 (2018-08-02)
Despite advances in management, bladder cancer remains a principal cause of cancer‑associated complications. Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) is dysregulated in certain types of cancer; however, limited data are available on the expression and function of TNFRSF14 in
Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells.
Abdullah R Ahmed et al.
Scientific reports, 9(1), 3408-3408 (2019-03-06)
Knowledge of protein signalling pathways in the working cell is seen as a primary route to identifying and developing targeted medicines. In recent years there has been a growing awareness of the importance of the mTOR pathway, making it an
Carman K M Ip et al.
Expert opinion on therapeutic targets, 16(6), 619-630 (2012-05-09)
The p70 S6 kinase (p70(S6K)) is frequently active in ovarian and a wide range of cancer types, and it has a crucial role in several processes considered hallmarks of cancer. Therefore, blocking p70(S6K) expression or activity may present a promising
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4502683-100UG | 04061837190780 |