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Merck
CN

SAB4503023

Anti-C1S (heavy chain, Cleaved-Arg437) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

C1 esterase, C1S, Complement C1s subcomponent, Complement component 1 subcomponent s

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 47 kDa
antigen 76 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

P09871

UniProt accession no.

P09871

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

proteolytically cleaved (Arg437)

Gene Information

human ... C1S(716)

General description

Anti-C1S (heavy chain, Cleaved-Arg437 Antibody detects endogenous levels of fragment of activated C1S (heavy chain, Cleaved-Arg437protein.
The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.

Immunogen

The antiserum was produced against synthesized peptide derived from human C1S.

Immunogen Range: 388-437

Biochem/physiol Actions

Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated lupus nephritis, with low gene expression observed in mice.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
410231

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A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4
Perry AJ
The Journal of Biological Chemistry, 288(22), 15821?15829-15821?15829 (2013)
Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.
Duncan RC
Journal of Immunology, 189(5), 2365-2373 (2012)
Gene expression analysis detected a low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice
Tamura K
Nephron: Experimental Nephrology, 123(3-4), 34-45 (2013)
Elucidation of the substrate specificity of the C1s protease of the classical complement pathway.
Kerr FK
The Journal of Biological Chemistry, 280(47), 39510-39514 (2005)
Complement genetics, deficiencies, and disease associations
Mayilyan KR
Protein & cell, 3(7), 487?496-487?496 (2012)
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