抗 磷酸化 Smad2 (pSer ²⁵⁰ ) 兔抗

SMAD2 (SMAD family member 2) is also called as MADR2 (substrate of the TGFβ receptor). It is located on human chromosome 18q21. This gene belongs to the mothers against Dpp (MAD) related family of proteins. SMAD2 has two highly conserved amino and carboxyl-terminal domains (MH1 and MH2 domains) but has no known structural motifs.

The antiserum was produced against synthesized peptide derived from human Smad2 around the phosphorylation site of Ser250.

Immunogen Range: 216-265

Anti-phospho-Smad2 (pSer250) antibody has been used in immunoblotting.

SMAD2 (SMAD family member 2) plays an important role in TGF-β(transforming growth factor β)/activin signaling pathways. Mutations in SMAD2 (SMAD family member 2) results in arterial aneurysms and dissections. Upregulation of Smad2 blocks the multiplication of gingival epithelial cells. Smad2 positively and negatively controls TGFβ-dependent transcription with the help of forkhead DNA-binding protein FAST2.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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