SAB5300394
Monoclonal Anti-PTK2B antibody produced in mouse
clone 5E2D5, ascites fluid
Synonym(s):
CAKB, FAK2, FRNK, PKB, PTK
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
5E2D5, monoclonal
Application:
direct ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
human
Citations:
4
Technique(s):
direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000
Product Name
Monoclonal Anti-PTK2B antibody produced in mouse, clone 5E2D5, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
5E2D5, monoclonal
mol wt
115.8 kDa
species reactivity
human
technique(s)
direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000
isotype
IgG2a
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PYK2(2185)
Biochem/physiol Actions
Protein tyrosine kinase 2 β (PTK2B) takes part in the β2-mediated signaling pathway and activates mitogen activated protein kinase pathway. The protein has been shown to be upregulated in many tumors. PTK2B also has a role in cell proliferation and migration. It regulates ion channels which are induced by calcium.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Protein tyrosine kinase 2 β (PTK2B) is a member of the focal adhesion kinase family which is expressed in the brain. The gene encoding it is localized on human chromosome 8.
Immunogen
Purified recombinant fragment of PYK2 (aa815-997) expressed in E.coli.
Mouse monoclonal antibody raised against PYK2
Mouse monoclonal antibody raised against PYK2
Physical form
Ascitic fluid containing 0.03% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Heval M Ozgen et al.
Journal of autism and developmental disorders, 39(2), 322-329 (2008-08-13)
Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders with a strong genetic etiology. Cytogenetic abnormalities have been detected in 5-10% of the patients with autism. In this study, we present the clinical, cytogenetic and array-comparative genomic hybridization (array-CGH)
Maria Steblyanko et al.
The Journal of biological chemistry, 290(19), 11833-11842 (2015-03-18)
Integrin engagement on lymphocytes initiates "outside-in" signaling that is required for cytoskeleton remodeling and the formation of the synaptic interface. However, the mechanism by which the "outside-in" signal contributes to receptor-mediated intracellular signaling that regulates the kinetics of granule delivery
Elinor Y Gottschalk et al.
Journal of virology, 89(17), 9103-9114 (2015-06-26)
The infectious process of human papillomaviruses (HPVs) has been studied considerably, and many cellular components required for viral entry and trafficking continue to be revealed. In this study, we investigated the role of the nonreceptor tyrosine kinase Pyk2 during HPV16
Yu Zhang et al.
Blood, 124(17), 2675-2686 (2014-09-14)
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor development. However, its role in modulating multiple myeloma (MM) biology and disease progression remains unexplored. We first demonstrated that
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