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Merck
CN

SAB5700504

Sigma-Aldrich

Anti-Phospho-NEDD4L-S448 antibody produced in rabbit

Synonym(s):

NEDD4-2, NEDD4.2, NEDD4L, PVNH7, RSP5, hNEDD4-2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

96-111

species reactivity

rat, human, mouse

concentration

1.74 mg/ml

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

Q96PU5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer448)

Gene Information

human ... NEDD4L(23327)

General description

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Immunogen

A synthetic phosphorylated peptide around S448 of human NEDD4L (NP_001138439.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Preparation Note

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
2158380301

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