biological source
rabbit
Quality Segment
conjugate
unconjugated
material
colorless
clone
3J4G7, monoclonal
form
liquid
species reactivity
human
concentration
1.191 mg/mL
technique(s)
immunohistochemistry: 1:50 - 1:200
color
colorless
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLDN18.2(51208)
General description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Immunogen
A synthetic peptide of human CLDN18.2.
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Application
IHC
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 3