SAB5702255
Anti-SARS-CoV-2 Spike S1 Antibody, clone 3E7H5, Rabbit Monoclonal
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Clone:
3E7H5, monoclonal
Species reactivity:
SARS coronavirus
Application:
IF, WB
Citations:
-
biological source
rabbit
material
colorless
clone
3E7H5, monoclonal
form
liquid
mol wt
110 kDa
species reactivity
SARS coronavirus
concentration
2.28 mg/mL
technique(s)
immunofluorescence: 1:50 - 1:200, western blot: 1:1000 - 1:9000
color
colorless
isotype
IgG
immunogen sequence
YFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETK
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... Spike S1(43740568)
General description
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It′′s been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of SARS-CoV-2 Spike S1 (YP_009724390.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Application
WB, IF/ICC
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk
WGK 3
Regulatory Information
常规特殊物品
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