SAB5702265
[KO Validated]Anti-AKT1 Antibody, clone 0O8L9, Rabbit Monoclonal
Synonym(s):
AKT,CWS6,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA,AKT1
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
eCl@ss:
32160702
Species reactivity:
rat, human
Conjugate:
unconjugated
Application:
WB
Citations:
-
biological source
rabbit
Quality Segment
conjugate
unconjugated
material
colorless
clone
0O8L9, monoclonal
form
liquid
mol wt
60 kDa
species reactivity
rat, human
concentration
1 mg/mL
technique(s)
western blot: 1:500 - 1:1000
color
colorless
isotype
IgG
immunogen sequence
SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AKT1(207)
General description
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 381-480 of human AKT1 (NP_005154.2).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Application
WB
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
Storage Class
10 - Combustible liquids
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