SAB5702429
Anti-53BP1 Antibody, clone 8Y3Y4, Rabbit Monoclonal
Synonym(s):
53BP1, TDRD30, TP53, p202, p53BP1
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
8Y3Y4, monoclonal
Application:
IF, IHC, WB
Citations:
-
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
8Y3Y4, monoclonal
form
liquid
mol wt
450 kDa
Quality Level
Gene Information
human ... TP53BP1(7158)
concentration
0.5 mg/mL
technique(s)
immunofluorescence: 1:50 - 1:200, immunohistochemistry: 1:50 - 1:200, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDT
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Double-strand break (DSB repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at ′Lys-15′ (H2AK15Ub and histone H4 dimethylated at ′Lys-20′ (H4K20me2, two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR during antibody genesis, a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity. In contrast, it is not required for classic NHEJ and V(DJ recombination (By similarity. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human 53BP1 (Q12888).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB, IHC, IF/ICC
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
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