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SAB6010061

Anti-phospho-PTPN11 (Y542) antibody, clone 2E2, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

Synonym(s):

Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Conjugate:
unconjugated
Clone:
2E2, recombinant monoclonal
Application:
ELISA, FACS, IF, IHC
Citations:
-

Key Documents

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recombinant

expressed in HEK 293 F cells

conjugate

unconjugated

antibody product type

primary antibodies

clone

2E2, recombinant monoclonal

form

liquid

mol wt

150 kDa

purified by

affinity chromatography

species reactivity

human

concentration

0.575mg/ml

technique(s)

ELISA: 2000:10000, flow cytometry: 1:50-1:200, immunofluorescence: 1:50-1:200, immunohistochemistry: 1:50-1:200

isotype

IgG

UniProt accession no.

Q06124

shipped in

wet ice

storage temp.

-10 to -25°C

Quality Level

100

target post-translational modification

phosphorylation (pTyr542)

General description

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at ′Tyr-722′ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).

Immunogen

A synthesized peptide derived from human Phospho-PTPN11 (Y542)

Physical form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Preparation Note

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Other Notes

GHE-pY-TNI

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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