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SBR00021

Nisin

Name: Nisin
Brand: SIGMA

Ready Made Solution, (20,000-40,000 IU/mL in 0.02N HCl)

Synonym(s):

Nisaplin

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About This Item

Empirical Formula (Hill Notation):

C₁₄₃H₂₃₀N₄₂O₃₇S₇

CAS Number:

1414-45-5

Molecular Weight:

3354.07

NACRES:

NA.76

UNSPSC Code:

12164500

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Properties

biological source

Lactococcus lactis

form

ready-to-use solution, solution

concentration

(20,000-40,000 IU/mL in 0.02N HCl)

density

1.02 g/mL

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(N[C@H](C(NC(C(N[C@@H](CCCCN)C(O)=O)=O)=C)=O)C(C)C)[C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC2=O)=O)CS[C@H]([C@@H]3C(N[C@H]2CS[C@H]([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC4=O)=

InChI

1S/C143H230N42O37S7/c1-24-69(11)105(148)135(213)162-82(27-4)118(196)174-94-58-225-59-95(175-123(201)89(48-67(7)8)169-115(193)74(16)158-138(216)107(70(12)25-2)180-132(94)210)133(211)184-112-79(21)229-61-96(160-104(190)56-152-134(212)100-38-34-44-185(100)142(112)220)128(206)164-84(36-29-32-42-145)120(198)182-109-76(18)226-60-97(161-103(189)55-151-117(195)85(39-45-223-22)165-122(200)88(47-66(5)6)168-113(191)72(14)156-102(188)54-153-136(109)214)129(207)171-92(51-101(147)187)125(203)166-86(40-46-224-23)119(197)163-83(35-28-31-41-144)121(199)183-110-77(19)228-63-99-130(208)170-90(49-80-52-149-64-154-80)124(202)176-98(62-227-78(20)111(141(219)177-99)181-116(194)75(17)159-140(110)218)131(209)173-93(57-186)127(205)179-108(71(13)26-3)139(217)172-91(50-81-53-150-65-155-81)126(204)178-106(68(9)10)137(215)157-73(15)114(192)167-87(143(221)222)37-30-33-43-146/h27,52-53,64-72,75-79,83-100,105-112,186H,15-16,24-26,28-51,54-63,144-146,148H2,1-14,17-23H3,(H2,147,187)(H,149,154)(H,150,155)(H,151,195)(H,152,212)(H,153,214)(H,156,188)(H,157,215)(H,158,216)(H,159,218)(H,160,190)(H,161,189)(H,162,213)(H,163,197)(H,164,206)(H,165,200)(H,166,203)(H,167,192)(H,168,191)(H,169,193)(H,170,208)(H,171,207)(H,172,217)(H,173,209)(H,174,196)(H,175,201)(H,176,202)(H,177,219)(H,178,204)(H,179,205)(H,180,210)(H,181,194)(H,182,198)(H,183,199)(H,184,211)(H,221,222)/b82-27-

InChI key

NVNLLIYOARQCIX-GSJOZIGCSA-N

Description

Application

Due to its wide range of antimicrobial activity, nisin is used as a shelf-life extender in a broad range of dairy and non-dairy products.

Biochem/physiol Actions

Nisin (Nisaplin) is produced by Lactococcus lactis. It is an effective lantibiotic peptide bactericidal agent. Nisin is a broad spectrum antimicrobial bacteriocin which affects Gram-positive bacteria, however, it has little or no effect on Gram-negative bacteria, yeasts or fungi.

It was demonstrated that nisin has capability to inhibit the growth of almost all tested Gram-positive beer-spoilage bacteria. Of 122 Gram-positive bacteria strains (predominantly Lactobacilli and Pediococci), 93% were sensitive to 100 units of nisin. In contrast, out of the 32 Gram-negative strains tested, only the genus Flavobacter proved to be affected by nisin.

Nisin exerts its antimicrobial activity by binding to lipid II which is a membrane-bound advanced intermediate involved in the biosynthesis of bacterial cell wall. By doing so, nisin sequesters lipid II from its functional location. In addition, the nisin-lipid II complex leads to formation of pores in the membrane causing cell death.

Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000425140

0000404580

0000309089

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Recombinant Lactococcus lactis NZ3900 expressing bioactive human FGF21 reduced body weight of Db/Db mice through the activity of brown adipose tissue.

W-Y Cao et al.

Beneficial microbes, 11(1), 67-78 (2020-02-19)

Fibroblast growth factor 21 (FGF21), a metabolism regulator, has an important effect on metabolic diseases, such as obesity and diabetes. It is also expressed in mice, and the murine source has high homology with human FGF21. Recently, it has been

Lantibiotic nisin: Natural preservative from Lactococcus lactis

Suganthi, V.; et al.

International Research Journal of Pharmacy, 1, 13-19 (2012)

Global Trade Item Number

SKU	GTIN
SBR00021-1ML	04061838661548