SBR00057
Retapamulin
≥98% (HPLC)
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关于此项目
经验公式（希尔记法）:
C30H47NO4S
化学文摘社编号:
分子量:
517.76
UNSPSC Code:
51284706
NACRES:
NA.76
MDL number:
Quality Segment
assay
≥98% (HPLC)
form
powder
antibiotic activity spectrum
Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
S(C4C[C@@H]5N([C@@H](CC5)C4)C)CC(=O)O[C@H]1[C@]2([C@H]3[C@@]([C@H]([C@@H]([C@](C1)(C)C=C)O)C)(CC[C@H]2C)CCC3=O)C
InChI
1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1
InChI key
STZYTFJPGGDRJD-FJJJPKKESA-N
General description
Retapamulin (RET) is a semi-synthetic antibiotic ointment, and pleuromutilin derivative compound. The primary structural difference between pleuromutilin and retapamulin is in the C-14 side chain.
Biochem/physiol Actions
Retapamulin is a potent antibacterial agent against Gram-positive bacteria, especially against Staphylococcus aureus and S. pyogenes. It displays synergistic effects against Enterococcus faecalis in combination with streptogramin (MLS). RET initiates ribosomal arrests at the start codon and enables genes to use alternative translational sites in E. coli.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable