SML0393
QNZ46
≥98% (HPLC)
别名:
4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid
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关于此项目
经验公式（希尔记法）:
C24H17N3O6
化学文摘社编号:
分子量:
443.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (warmed; clear solution)
storage temp.
room temp
SMILES string
COc1ccc2N=C(\C=C\c3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O
InChI
1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
InChI key
GNLVJIICVWDSNI-LFYBBSHMSA-N
Biochem/physiol Actions
QNZ46 is a noncompetitive inhibitor of GluN2C/D (NMDA antagonist).
QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC50 values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable