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Merck
CN

SML0393

QNZ46

≥98% (HPLC)

Synonym(s):

4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C24H17N3O6
CAS Number:
1237744-13-6
Molecular Weight:
443.41
NACRES:
NA.77
PubChem Substance ID:
329825390
UNSPSC Code:
12352200
MDL number:
MFCD22666391

Key Documents

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Product Name

QNZ46, ≥98% (HPLC)

InChI

1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+

SMILES string

COc1ccc2N=C(\C=C\c3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O

InChI key

GNLVJIICVWDSNI-LFYBBSHMSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (warmed; clear solution)

storage temp.

room temp

Quality Level

100

Related Categories

Biochem/physiol Actions

QNZ46 is a noncompetitive inhibitor of GluN2C/D (NMDA antagonist).
QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC50 values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
072M4742V

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Reshmi Tognatta et al.
Frontiers in cellular neuroscience, 14, 74-74 (2020-04-18)
Astrocytes have been implicated in regulating oligodendrocyte development and myelination in vitro, although their functions in vivo remain less well defined. Using a novel approach to locally ablate GFAP+ astrocytes, we demonstrate that astrocytes are required for normal CNS myelin

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