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Merck
CN

SML0565

MK-0343

≥98% (HPLC)

Synonym(s):

7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine, MRK-409

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About This Item

Empirical Formula (Hill Notation):
C19H17F2N7O
CAS Number:
233275-76-8
Molecular Weight:
397.38
NACRES:
NA.77
PubChem Substance ID:
329825556
UNSPSC Code:
12352202
MDL number:
MFCD22683821

Key Documents

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Product Name

MK-0343, ≥98% (HPLC)

InChI

1S/C19H17F2N7O/c1-27-16(22-10-23-27)9-29-19-12(11-4-2-5-11)8-15-24-25-18(28(15)26-19)17-13(20)6-3-7-14(17)21/h3,6-8,10-11H,2,4-5,9H2,1H3

SMILES string

Cn1ncnc1COc2nn3c(nnc3cc2C4CCC4)-c5c(F)cccc5F

InChI key

GOIFCXRIFSYPFG-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

MK-0343 (MRK-409) is a partial agonist for GABAA receptors with comparable Ki values for α1, α2, α3 and α5 containing receptors (0.2 – 0.4 nM). The compound has the greatest agonist activity against α3 receptors, and is brain penatrant, and displays anxiolytic activity in rodent and primate models.
MK-0343 is a GABAA partial agonist.

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
122M4607V

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Articles

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