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SML1207

GPBAR-A

≥98% (HPLC)

Synonym(s):

4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one

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About This Item

Empirical Formula (Hill Notation):
C23H15F7N2O2
CAS Number:
877052-79-4
Molecular Weight:
484.37
NACRES:
NA.77
PubChem Substance ID:
329825719
UNSPSC Code:
51111800
MDL number:
MFCD27937760
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C(CO1)N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC3=C1N=CC=C3C4=C(F)C=CC=C4

InChI

1S/C23H15F7N2O2/c24-19-4-2-1-3-17(19)16-5-6-31-21-18(16)11-32(20(33)12-34-21)10-13-7-14(22(25,26)27)9-15(8-13)23(28,29)30/h1-9H,10-12H2

InChI key

ZIXNJVGTAXRKAP-UHFFFAOYSA-N

Biochem/physiol Actions

GPBAR-A is a very potent agonist of the bile acid receptor GPBA (also known as TGR5).
GPBAR-A is a very potent agonist of the bile acid receptor GPBA (also known as TGR5). In murine primary intestinal cultures, GPBAR-A induces an elevation in intracellular cAMP and calcium levels, and stimulates secretion of GLP-1.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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