Name: GPBAR-A
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₁₅F₇N₂O₂

CAS Number:

877052-79-4

Molecular Weight:

484.37

MDL number:

MFCD27937760

UNSPSC Code:

51111800

PubChem Substance ID:

329825719

NACRES:

NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C(CO1)N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC3=C1N=CC=C3C4=C(F)C=CC=C4

InChI

1S/C23H15F7N2O2/c24-19-4-2-1-3-17(19)16-5-6-31-21-18(16)11-32(20(33)12-34-21)10-13-7-14(22(25,26)27)9-15(8-13)23(28,29)30/h1-9H,10-12H2

InChI key

ZIXNJVGTAXRKAP-UHFFFAOYSA-N

Biochem/physiol Actions

GPBAR-A is a very potent agonist of the bile acid receptor GPBA (also known as TGR5).

GPBAR-A is a very potent agonist of the bile acid receptor GPBA (also known as TGR5). In murine primary intestinal cultures, GPBAR-A induces an elevation in intracellular cAMP and calcium levels, and stimulates secretion of GLP-1.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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