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About This Item
Empirical Formula (Hill Notation):
C17H17N5O
CAS Number:
Molecular Weight:
307.35
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
SMILES string
OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1
InChI
1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22)
InChI key
MDGIEDNDSFMSLP-UHFFFAOYSA-N
Application
Ogerin has been used in G-protein-coupled receptors (GPCR) deorphanization and phosphatidylinositol hydrolysis assay.
Biochem/physiol Actions
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1).
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.
Other Notes
Ogerin negative control, a structurally similar analog of ogerin, is available from Sigma. To learn more about and purchase ogerin negative control, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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