SML1738
RL648_81
≥98% (HPLC)
Synonym(s):
Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate
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About This Item
Empirical Formula (Hill Notation):
C17H17F4N3O2
CAS Number:
Molecular Weight:
371.33
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
InChI
1S/C17H17F4N3O2/c1-2-26-16(25)24-13-8-7-12(14(18)15(13)22)23-9-10-3-5-11(6-4-10)17(19,20)21/h3-8,23H,2,9,22H2,1H3,(H,24,25)
InChI key
MVSMZQRRMPUGHI-UHFFFAOYSA-N
SMILES string
NC1=C(NC(OCC)=O)C=CC(NCC2=CC=C(C(F)(F)F)C=C2)=C1F
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
room temp
Quality Level
Related Categories
Biochem/physiol Actions
Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate (RL648_81) is 15 times more effective and more selective than retigabine, an anticonvulsant. RL648_81 helps to treat or inhibit neurologic disorders linked with neuronal hyperexcitability.
RL648_81 is a KCNQ2/3 channel activator.
RL648_81 is a selective and potent KCNQ2/3 channel activator.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Synthesis and evaluation of potent KCNQ2/3-specific channel activators.
Kumar M, et al.
Molecular Pharmacology, 89(6), 667-677 (2016)
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