Name: RL648_81
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₇F₄N₃O₂

CAS Number:

1919050-87-5

Molecular Weight:

371.33

UNSPSC Code:

12352200

PubChem Substance ID:

329826046

NACRES:

NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

room temp

SMILES string

NC1=C(NC(OCC)=O)C=CC(NCC2=CC=C(C(F)(F)F)C=C2)=C1F

InChI

1S/C17H17F4N3O2/c1-2-26-16(25)24-13-8-7-12(14(18)15(13)22)23-9-10-3-5-11(6-4-10)17(19,20)21/h3-8,23H,2,9,22H2,1H3,(H,24,25)

InChI key

MVSMZQRRMPUGHI-UHFFFAOYSA-N

Biochem/physiol Actions

Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate (RL648_81) is 15 times more effective and more selective than retigabine, an anticonvulsant. RL648_81 helps to treat or inhibit neurologic disorders linked with neuronal hyperexcitability.

RL648_81 is a KCNQ2/3 channel activator.

RL648_81 is a selective and potent KCNQ2/3 channel activator.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000468404

0000011263

086M4623V

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