SML1897
NSC73306
≥98% (HPLC)
别名:
2-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-N-(4-methoxyphenyl)hydrazinecarbothioamide, NSC 671054, NSC 73304
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, yellow to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
S=C(N\N=C2\c3c(c(cc(c3)Cl)Cl)NC\2=O)Nc1ccc(cc1)OC
InChI
1S/C16H12Cl2N4O2S/c1-24-10-4-2-9(3-5-10)19-16(25)22-21-14-11-6-8(17)7-12(18)13(11)20-15(14)23/h2-7H,1H3,(H2,19,22,25)(H,20,21,23)
InChI key
HPXWWBMVIMFLLU-UHFFFAOYSA-N
Biochem/physiol Actions
NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells.
NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. Irrespective of variations in cell line background, NSC73306 consistently demonstrated a Pgp-potentiated MDR-selective toxicity. It appears that NSC73306 is transported into the cell by copper transporter 1 (CTR1, SLC31A1). It is not P-gp inhibitor.
flash_point_c
Not applicable
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable