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Merck
CN

SML2249

LSN3154567

≥98% (HPLC)

Synonym(s):

2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide, Nampt-IN-1; 2-Hydoxy-2-methyl-N-{2-[(pyridin-3-yloxy)acetyl]-1,2,3,4-tetrahydroisoquinolin-6-YL}propane-1-sulfonamide

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About This Item

Empirical Formula (Hill Notation):
C20H25N3O5S
CAS Number:
1698878-14-6
Molecular Weight:
419.49
MDL number:
MFCD28963946
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(Nc1cc2c(cc1)CN(CC2)C(=O)COc3cnccc3)CC(O)(C)C

InChI

1S/C20H25N3O5S/c1-20(2,25)14-29(26,27)22-17-6-5-16-12-23(9-7-15(16)10-17)19(24)13-28-18-4-3-8-21-11-18/h3-6,8,10-11,22,25H,7,9,12-14H2,1-2H3

InChI key

QHHSCLARESIWBH-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

LSN3154567 is an orally available, potent and highly selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). LSN3154567 exhibits broad spectrum and potent anticancer activities without causing retinopathy in the rat. LSN3154567co-administration with nicotinic acid (NA) produces potent anti-tumor activity in tumor xenograft models without retinal and hematological toxicities.
LSN3154567 might be useful in developing a novel cancer therapeutic.
orally available, potent and highly selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000053812
0000053813
0000046461

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Genshi Zhao et al.
Molecular cancer therapeutics, 16(12), 2677-2688 (2017-10-22)
NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investigations. Yet, the on-target hematological and

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