SML2564
PIAA
≥98% (HPLC)
Synonym(s):
(E)-3-(3-phenylbenzo[c]isoxazol-5-yl)acrylic acid, 3-(3-phenyl-2,1-benzisoxazol-5-yl)-2-propenoic acid
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About This Item
Empirical Formula (Hill Notation):
C16H11NO3
CAS Number:
Molecular Weight:
265.26
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
n1[o]c(c3c1ccc(c3)\C=C\C(=O)O)c2ccccc2
InChI key
FCMHXGNYHDXIPU-VQHVLOKHSA-N
InChI
1S/C16H11NO3/c18-15(19)9-7-11-6-8-14-13(10-11)16(20-17-14)12-4-2-1-3-5-12/h1-10H,(H,18,19)/b9-7+
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
PIAA is an inhibitor of TANK binding kinase 1 (TBK1) and IKB kinase epsilon (IKKε) that has been shown to promote regeneration of pancreatic β-cells. PIAA improved function and replication of mammalian β-cells including primary human β-cells and induced β-cell proliferation in streptozotocin-induced diabetic mice resulting in increased pancreas insulin content and improved glycemic control. PIAA exhibited an IC50 value of 400 nM for TBK1 and 1.07 μM for IKKε with minimum toxicity
TBK1/IKKε inhibitor that promotes regeneration of pancreatic β-cells
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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