SML2638
XIE62-1004
≥98% (HPLC)
Synonym(s):
2-(3,4-bis(Benzyloxy)benzylamino)ethanol hydrochloride, 2-[[[3,4-bis(Phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C23H25NO3 · HCl
CAS Number:
Molecular Weight:
399.91
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OCCNCC1=CC(OCC2=CC=CC=C2)=C(C=C1)OCC3=CC=CC=C3.Cl
InChI
1S/C23H25NO3.ClH/c25-14-13-24-16-21-11-12-22(26-17-19-7-3-1-4-8-19)23(15-21)27-18-20-9-5-2-6-10-20;/h1-12,15,24-25H,13-14,16-18H2;1H
InChI key
ROURICFSUKPJOO-UHFFFAOYSA-N
Biochem/physiol Actions
Sequestosome-1 (p62, SQSTM1) ZZ domain-targeting autophagy inducer that reduces cellular mutant huntingtin (mHTT) aggregates.
XIE62-1004 is a synthetic sequestosome-1 (p62, SQSTM1) ZZ domain ligand that induces disulfide bond-linked and PB1 domain-dependent p62 self-aggregation, leading to interaction with LC3 on autophagic membranes and p62/cargoes delivery (2.5-10 μM for 6-24 hrs in p62-expressing HeLa cultures). XIE62-1004 treatment (10 μM, 18 hrs) effectively reduces insoluble aggregates of transiently expressed mutant huntingtin (mHTT) constructs in HeLa (GFP-HDQ103) and PC12 (EGFP-HDQ74) trransfectants, as well as in wild-type, but not autophagy defective Atg5-/- MEFs (GFP-HDQ103).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yi Zhang et al.
Autophagy, 15(4), 735-737 (2019-01-18)
SQSTM1/p62 facilitates responses to various cellular stresses and has been implicated in human diseases. This protein functions as a major cytoplasmic signaling hub and has multiple binding partners, including arginylated (Nt-R) proteins that are recognized by the ZZ domain of
Young Dong Yoo et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(12), E2716-E2724 (2018-03-07)
The conjugation of amino acids to the protein N termini is universally observed in eukaryotes and prokaryotes, yet its functions remain poorly understood. In eukaryotes, the amino acid l-arginine (l-Arg) is conjugated to N-terminal Asp (Nt-Asp), Glu, Gln, Asn, and
Hyunjoo Cha-Molstad et al.
Nature communications, 8(1), 102-102 (2017-07-26)
Macroautophagy mediates the selective degradation of proteins and non-proteinaceous cellular constituents. Here, we show that the N-end rule pathway modulates macroautophagy. In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N-recognin that binds type-1 and type-2 N-terminal degrons (N-degrons), including
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2638-5MG | 04061841136255 |
| SML2638-25MG | 04061841136248 |