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SML2937

iHAP1

≥98% (HPLC)

别名:

(2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone, 2-Chloro-10-(4-methoxybenzoyl)-10H-phenothiazine

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关于此项目

经验公式（希尔记法）:
C20H14ClNO2S
化学文摘社编号:
105925-39-1
分子量:
367.85
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01245092
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

S1c2c(cc(cc2)Cl)N(c4c1cccc4)C(=O)c3ccc(cc3)OC

InChI key

CSWHYHPUEDNIQY-UHFFFAOYSA-N

Biochem/physiol Actions

iHAP1 is a potent activator of protein phosphatase 2A (PP2A) that allosterically facilitates assembly and activation of PP2A holoenzyme complex consisting PPP2R1A, PPP2R5E (B56ε, regulatory), and PPP2CA subunits. iHAP1 induces dephosphorylation of MYBL2 transcription factor on Ser241, causing irreversible cell cycle arrest of leukemia and other cancer cells in prometaphase. iHAP1 exhibits significant antitumor activity and lack of toxicity in T-ALL xenograft mice models. Normal CD34+ HSPCs are appears to be resistant to iHAP1. iHAP1 does not inhibit dopamine receptor D2.
potent allosteric activator of protein phosphatase 2A (PP2A) containing regulatory subunit PPP2R5E (B56ε)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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