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Merck
CN

SML3190

Dehydroevodiamine hydrochloride

≥98% (HPLC)

Synonym(s):

8,14-Dihydro-14-methyl-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one hydrochloride, Dehydroevodiamine chloride, Indolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,14-dihydro-14-methyl-, hydrochloride (1:1)

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About This Item

Empirical Formula (Hill Notation):
C19H15N3O · HCl
CAS Number:
111664-82-5
Molecular Weight:
337.80
UNSPSC Code:
12352107
NACRES:
NA.77
MDL number:
MFCD32061978

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InChI

1S/C19H15N3O.ClH/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22;/h2-9H,10-11H2,1H3;1H

InChI key

SVOMSEHNGXLQRU-UHFFFAOYSA-N

SMILES string

O=C1C2=C(C=CC=C2)N(C)C3=C4C(CCN31)=C(C=CC=C5)C5=N4.Cl

assay

≥98% (HPLC)

form

powder

Quality Level

100

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

Dehydroevodiamine is the major alkaloid of Evodia rutaecarpa that exhibit cardiovascular effects such as bradycardia, hypotension, and vasorelaxation. Dehydroevodiamine potently inhibits hERG channels. Apparently it is a blocker of IKr (rapid delayed rectifier current) with proarrhythmic effects in vitro and in vivo. Dehydroevodiamine ameliorates the spatial memory impairment in the scopolamine-induced amnestic rats. It reduced neurotoxicity and the production of A?-induced ROS in primary cortical neurons.
potently inhibits hERG channels; reduced neurotoxicity and the production of A?-induced ROS in primary cortical neurons

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000148192
0000148193
0000148193
0000148192
0000139659

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