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Merck
CN

SML3559

LAU-0901

≥98% (HPLC)

Synonym(s):

1,4-dihydro-2,4,6-trimethyl-3,5-Pyridinedicarboxylic acid 3-[2-(3,4-dichlorophenoxy)ethyl] 5-[2-(4-morpholinyl)-1-(4-morpholinylmethyl)ethyl] ester

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About This Item

Empirical Formula (Hill Notation):
C29H39Cl2N3O7
CAS Number:
727358-25-0
Molecular Weight:
612.54
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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InChI

1S/C29H39Cl2N3O7/c1-19-26(28(35)40-15-14-39-22-4-5-24(30)25(31)16-22)20(2)32-21(3)27(19)29(36)41-23(17-33-6-10-37-11-7-33)18-34-8-12-38-13-9-34/h4-5,16,19,23,32H,6-15,17-18H2,1-3H3

InChI key

WZWJKBCMEZITJW-UHFFFAOYSA-N

SMILES string

CC1C(C(OCCOC2=CC(Cl)=C(C=C2)Cl)=O)=C(NC(C)=C1C(OC(CN3CCOCC3)CN4CCOCC4)=O)C

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Highly potent and selective platelet-activating factor (PAF) receptor antagonist
LAU-0901 is a highly potent and selective platelet-activating factor (PAF) receptor antagonist that is neuroprotective in experimental stroke, and protective in a variety of inflammation models. LAU-0901 blocks pro-inflammatory signaling. LAU-0901 demonstrated efficacy in a mouse model of glioblastoma multiforme (GBM) alone and in combination with Avastin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000221326
0000221328
0000210198
0000210198
0000221326

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Combined Therapy With Avastin, a PAF Receptor Antagonist and a Lipid Mediator Inhibited Glioblastoma Tumor Growth
Frontiers in Pharmacology, 12 (2021)
Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke
Translational Stroke Research, 3, 154-163 (2012)
Blocking pro-inflammatory platelet-activating factor receptors and activating cell survival pathways: A novel therapeutic strategy in experimental ischemic stroke
Brain circulation, 6, 260-268 (2020)

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