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SML3559

LAU-0901

≥98% (HPLC)

Synonym(s):

1,4-dihydro-2,4,6-trimethyl-3,5-Pyridinedicarboxylic acid 3-[2-(3,4-dichlorophenoxy)ethyl] 5-[2-(4-morpholinyl)-1-(4-morpholinylmethyl)ethyl] ester

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About This Item

Empirical Formula (Hill Notation):
C29H39Cl2N3O7
CAS Number:
727358-25-0
Molecular Weight:
612.54
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1C(C(OCCOC2=CC(Cl)=C(C=C2)Cl)=O)=C(NC(C)=C1C(OC(CN3CCOCC3)CN4CCOCC4)=O)C

InChI

1S/C29H39Cl2N3O7/c1-19-26(28(35)40-15-14-39-22-4-5-24(30)25(31)16-22)20(2)32-21(3)27(19)29(36)41-23(17-33-6-10-37-11-7-33)18-34-8-12-38-13-9-34/h4-5,16,19,23,32H,6-15,17-18H2,1-3H3

InChI key

WZWJKBCMEZITJW-UHFFFAOYSA-N

Biochem/physiol Actions

Highly potent and selective platelet-activating factor (PAF) receptor antagonist
LAU-0901 is a highly potent and selective platelet-activating factor (PAF) receptor antagonist that is neuroprotective in experimental stroke, and protective in a variety of inflammation models. LAU-0901 blocks pro-inflammatory signaling. LAU-0901 demonstrated efficacy in a mouse model of glioblastoma multiforme (GBM) alone and in combination with Avastin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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