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Merck
CN

SML3707

Sigma-Aldrich

Prulifloxacin

≥98% (HPLC)

Synonym(s):

(±)-7-[4-[(Z)-2,3-Dihydroxy-2-butenyl]-1-piperazinyl]-6-fluoro-1-methyl-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid cyclic carbonate, 6-Fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid, NM 441, NM441

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About This Item

Empirical Formula (Hill Notation):
C21H20FN3O6S
CAS Number:
123447-62-1
Molecular Weight:
461.46
MDL number:
MFCD00864847
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

Fc1cc2c(cc1N4CCN(CC4)CC5=C(OC(=O)O5)C)N3C(SC3=C(C2=O)C(=O)O)C

InChI

1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)

InChI key

PWNMXPDKBYZCOO-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Broad spectrum antibiotic that potently inhibits bacterial DNA gyrase and topoisomerase IV
Prulifloxacin is a synthetic fluoroquinolone broad spectrum antibiotic that potently inhibits bacterial DNA gyrase and topoisomerase IV.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H315,H362,H373

Hazard Classifications

Lact. - Skin Irrit. 2 - STOT RE 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000241011
0000241010
0000237188
0000241011
0000241010

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M Ozaki et al.
Antimicrobial agents and chemotherapy, 35(12), 2496-2499 (1991-12-01)
NM441 is a lipophilic prodrug of a new thiazeto-quinoline carboxylic acid derivative NM394, and when it is administered orally it is readily absorbed and hydrolyzed to its parent compound. After oral administration of NM441 at a dose of 20 mg/kg
Gabriele Tulone et al.
Antibiotics (Basel, Switzerland), 11(3) (2022-03-26)
Our study aimed to compare the incidence of infective complications after transrectal ultrasound-guided prostate biopsy (TRUSBx) when adopting different antimicrobial prophylaxis regimens. A multi-institutional cohort of 1150 patients who underwent TRUSBx was retrospectively analyzed. Procedures were performed between 2017 and
Maria Gabriella Matera
Pulmonary pharmacology & therapeutics, 19 Suppl 1, 20-29 (2005-12-20)
Prulifloxacin, the prodrug of ulifloxacin, is a broad-spectrum oral fluoroquinolone antibacterial agent. After absorption, prulifloxacin is metabolized by esterases to ulifloxacin. The drug has a long elimination half-life, allowing once-daily administration. In vitro, ulifloxacin is generally more active than other

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