SML3736
Hypoxia probe 2
95% (UPLC)
Synonym(s):
5’-Methoxy-1’,2’-dimethyl-3-(1-((3-oxo-3H-phenoxazin-7-yl)oxy)ethyl)-1H-indole-4’,7’-dione
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About This Item
Empirical Formula (Hill Notation):
C25H20N2O6
Molecular Weight:
444.44
NACRES:
NA.77
UNSPSC Code:
12352200
assay
95% (UPLC)
form
powder
storage condition
protect from light
color
, Faint orange to red
solubility
DMSO: 2 mg/mL, clear (Warmed)
shipped in
wet ice
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Hypoxia probe 2 is a resorufin-based non-fluorescent hypoxia probe that undergoes cytochrome P450 reductase (PH51)-catalyzed reduction to yield the fluorescent reporter resorufin (ex 545 nm, em 582 nm) in conditions of 4% O2 and lower, allowing imaging hypoxia levels similar to those detected by pimonidazole without the use of antibodies. When employed together with Tokyo green-based hypoxia probe 4 (Tokyo green ex 480 nm, em 515 nm), the probe pair allows the simultaneous (two-color) imaging of different hypoxia levels in living cells.
Resorufin-based hypoxia probe that allows fluorescent imaging of hypoxia levels in live cells similar to those detected by pimonidazole without the use of antibodies.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Two Color Imaging of Different Hypoxia Levels in Cancer Cells.
Journal of the American Chemical Society, 145(4), 2572-2583 (2023)
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